Jing-Wei Xiong

School of Basic Medical Sciences, Nanchang University; College of Future Technology, Peking University, China

Zebrafish and neonatal mice have become powerful animal models for regenerative studies because of their regenerative capacity after injury.Understanding the cellular and molecular mechanisms on their role in heart regeneration holds great potential for priming adult mammalian heart for regeneration. By establishing a chemical screening, we have identified  a  small-molecule  cocktail  5SM that  enables  mammalian cardiomyocyte  proliferation  and  heart  regeneration  (Cell  Stem  Cell 2022; J Mol Cell Biol 2023). Ongoing studies focus on determining the underlying mechanisms by multiomics  approaches,  as  well  as  searching  for  single  chemical  molecule that  sufficiently promotes heart regeneration in small and large animal models. I will present data how 5SM act on several heart cell types to coordinate heart regeneration in mice after myocardial infarction, and thus our works may shed light on both fundamental mechanisms on heart regeneration and translational implication on heart disease.