9:00-12:00

Registration

Opening Ceremony

Chairperson: Guangjin Pan, GIBH, CAS

14:00-14:20

Welcome Address and Opening Remarks

Welcome Address: Duanqing Pei, Westlake University, China

Opening Remarks: Fei Sun, Director of GIBH, CAS, China

14:20-14:25

Group Photo

Keynote Session

Chairperson: Duanqing Pei, Westlake University

Fei Sun, GIBH,CAS

14:25-15:00

Keynote Speech

Mechanisms preventing nuclear instability of muscle stem cells

Thomas Braun, MPI for Heart and Lung Research, Germany

15:00-15:35

Keynote Speech

TBD

Duanqing Pei, Westlake University, China

15:35-15:55

Refreshment Break

Session Ⅰ: Stem Cells and Diseases干细胞与疾病

Chairperson: Chenleng Cai, GIBH, CAS

Jose Silva, Guangzhou Laboratory

15:55-16:20

Tissue-specific inflammatory cue to drive early hematopoiesis in bone marrow

Hitoshi Takizawa, Kumamoto University, Japan

16:20-16:45

Intestinal organoid zoo of 26 species reveals conserved and divergent programs of biology

Bon-Kyoung Koo, Center for Genome Engineering, Korea

16:45-17:10

Microvascular endothelial cell function in acute lung injury and inflammation

Xiaoyu Tian, the Chinese University of Hong Kong, HK, China

17:10-17:35

Improving the cardiac microenvironment as a novel strategy to enhance the cardioprotective effects of cell therapy in diabetic heart failure

Xin-liang Ma,Thomas Jefferson University, USA

17:35-18:00

Organotypic endothelial cell differentiation from vascular stem/progenitor in lung

Qi Chen, GIBH, CAS, China

18:00-18:15

Sponsor Time

18:20-20:30

Dinner

19:00-20:00

Poster Session

Day 2: Saturday 6th December

Session Ⅱ: Cell Totipotency and Development细胞全能性与发育

Chairperson:  Xingguo Liu, GIBH, CAS

Bo Feng, the Chinese University of Hong Kong

08:30-09:05

Keynote Speech

Engineering human embryo-like structures using stem cells

Jun Wu, the University of Texas Southwestern Medical Center, USA

09:05-09:30

Expanded potential of human haploid pluripotent stem cells

Ling Shuai, Nankai University, China

09:30-09:55

Advancing the Maturation of Human PSC-Derived Intestinal Organoids through Multi-Germ-Layer Co-Development

Qiutan Yang, Institute of Zoology, CAS, China

09:55-10:20

Decoding the Regulatory Role of Transposons in Pluripotency Transition

Yawei Gao, Tongji University

10:20-10:35

Refreshment Break

Session Ⅲ: Stem Cell Therapy and Regeneration干细胞治疗与再生

Chairperson:  Liangxue Lai, GIBH, CAS

Ralf Jauch, The University of Hong Kong

10:35-11:10

Keynote Speech

Beta cell development and regeneration

Heiko Lickert, Helmholtz Diabetes Center, Munich, Germany

11:10-11:35

Clone and engineer epithelial stem cells for regenerative medicine

Wei Zuo, Tongji University, China

11:35-12:00

From old skin to old brain: Direct conversion to explore the interface between neuronal aging and disease

Jerome Mertens, the University of California San Diego, USA

12:00-12:25

Human Induced Pluripotent Stem Cells and derivation of functional blood cells for cell therapy

Guangjin Pan, GIBH, CAS, China

12:25-12:40

Extracellular matrix stiffness directs region-specific lung epithelial differentiation revealed by hPSC-derived lung organoids

Zhiying Liao, Guangzhou Laboratory, China

12:40-14:00

Lunch

Session Ⅳ: Novel Technology and Frontiers新技术与前沿

Chairperson: Xiaoying Fan, Guangzhou Laboratory

Guangdun Peng, GIBH, CAS

14:00-14:25

AI-designed Proteins in Regenerative Medicine and Dentistry

Julie Mathieu, University of Washington, USA

14:25-14:50

High-resolution in situ structures of mammalian respiratory supercomplexes

Jack Zhang, Yale University, USA

14:50-15:15

Mitochondrial transplantation as a novel therapeutic strategy for cardiometabolic disorders

Soh Boon Seng, ASTAR, Singapore

15:15-15:40

Local mRNA translation in axons sustains neurotransmission

Hovy Ho-Wai WONG, the Chinese University of Hong Kong, HK, China

15:40-16:05

The role of a novel member of SMYDs in epigenetic regulation of mesendodermal specification

Weinian Shou, Indiana University School of Medicine, USA

16:05-16:20

Predicting cellular responses with conditional diffusion models

Siyu He, Stanford University, USA

16:20-16:35

Sponsor Time

16:40-16:50

Refreshment Break

16:45-19:00

CLAF Tour &

Poster Session: Flash Talks

Chairperson: Jing Liu, GIBH, CAS

Jie Wang, GIBH, CAS

19:00-21:00

Dinner

Day 3: Sunday 7th December

SessionⅤ:  Cell Fate and Epigenetics细胞命运与表观遗传

Chairperson: Jiekai Chen, GIBH, CAS

Xiangqian Kong, GIBH, CAS

08:30-09:05

Keynote Speech

Roles of DNA methylation in cancer and stem cells

Pierre-Antoine Defossez, Université Paris Cité, CNRS, France

09:05-09:30

Guided Search: How Transcription Factors Navigate the Chromatin Landscape to Control Cell Identity

Abdenour Soufi, the University of Edinburgh, UK

09:30-09:55

Biology of histidine methylation

Yoichi Shinkai, RIKEN, Japan

09:55-10:10

Refreshment Break

Session Ⅵ: Organogenesis and Organoids类器官与器官发生

Chairperson: Huisheng Liu, Guangzhou Laboratory

Hui Zheng, GIBH, CAS

10:10-10:35

Deconvolving the temporal dynamics of organogenesis via deep-tissue spatial transcriptomics

Reza Kalhor, the Johns Hopkins University, USA

10:35-11:00

Perfusable vascularized human brain organoids

Angela Ruohao Wu, the Hong Kong University of Science and Technology, HK, China

11: 00-11:25

Using chemical biology to approach heart regeneration

Jing-Wei Xiong, Nanchang University, China

11: 25-11:40

In Vitro Generation of Mouse Embryo Model with Organogenesis via Embryo Founder Cells

Huanhuan Li, Guangzhou Laboratory, China

Closing Ceremony

Chairperson: Jiekai Chen, GIBH, CAS

11:40-12:15

Keynote Speech

Generation of Megakaryocytes /Platelets from Human Pluripotent Stem Cells

Jiaxi Zhou, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences，China

12:15-12:25

Poster Awarding

12:25-12:30

Closing remarks

12:30

Lunch