Yoichi Shinkai

RIKEN Cellular Memory Laboratory, Japan

We have been using a synthetic cofactor analog of SAM, ProSeAM to analyze   novel  substrates  of  lysine   methyltransferases   and  their biological functions. Recently, we have been using the same method to characterize protein methyltransferases other than lysine residue and their  functions.  In  my  talk  slot,   I  would   like  to  introduce   recent advances in histidine methylation, as well as our laboratory’s findings on the regulation of histidine methylation and its biological functions.