金冬雁

Dong-Yan Jin got his PhD with Prof. Yun-De Hou in Beijing in 1991 and then received postdoctoral training with Dr. Kuan-Teh Jeang at the NIH in 1994-1999. He joined the University of Hong Kong in 1999 and is now Clare and Lawrence Fok Professor in Precision Medicine. He is a molecular virologist with an interest in viral oncogenesis and innate antiviral response. In his study of human T-cell leukemia virus, he discovered in 1998 a key component named MAD1 of the cellular mitotic checkpoint. In 2011, his group found that the virus sensor RIG-I needs an RNA-binding protein partner called PACT to initiate and sustain antiviral response. They have also identified and characterized novel viral interferon antagonists and inflammasome activators in SARS-CoV, MERS-CoV and SARS-CoV-2. Many of their findings have not only broken new grounds to understand virus-host interaction and viral pathogenesis, but also revealed new strategies and leads for disease prevention and intervention.