张玉霞
广州医科大学附属广州市妇女儿童医疗中心首席研究员,广东省“珠江学者”特聘教授(儿科学),广州市优秀专家,广州市医学重点人才。获得国家自然科学基金面上项目/重大培育项目等项目资助;曾获美国JDRF和澳大利亚NHMRC国家级项目资助。
研究方向及成果
长期从事儿童免疫相关疾病的发生机制、遗传易感因素以及预防和治疗策略研究,以真实世界疾病队列和社区出生队列为研究对象,以通讯及共通讯作者在Cell (2020,2019),JACI (2020), Sci Transl Med (2016),第一及共第一作者在Nat Immunol (2013),Blood (2013,2014)等发表论文多篇。先后阐述了新生儿/儿童肠-肝免疫失稳态的机制,开创了利用PDE抑制剂双嘧达莫治疗儿童肠道炎症性疾病,以及利用B细胞清除疗法治疗新生儿胆道闭锁的新用途。
代表性论文
1. Wang, J.*, Xu, Y.*, Chen, Z.*, Liang, J.*, Lin, Z.*, Liang, H.*, Xu, Y., Wu, Q., Guo, X., Nie, J., Lu, B., Huang, B., Xian, H., Wang, X., Wu, Q., Zeng, J., Chai, C., Zhang, M., Lin, Y., Zhang, L., Zhao, S., Tong, Y., Zeng, L., Gu, X., Chen, Z.G., Yi, S., Zhang, T., Delfouneso, D., Zhang, Y., Nutt, S.L., Lew, A.M., Lu, L., Bai, F.#, Xia, H.#, Wen, Z.#, and Zhang, Y.# (2020). Liver Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia. Cell.
2. Huang, B.*, Chen, Z.*, Geng, L.*, Wang, J.*, Liang, H., Cao, Y., Chen, H., Huang, W., Su, M., Wang, H., Xu, Y., Liu, Y., Lu, B., Xian, H., Li, H., Li, H., Ren, L., Xie, J., Ye, L., Wang, H., Zhao, J., Chen, P., Zhang, L., Zhao, S., Zhang, T., Xu, B., Che, D., Si, W., Gu, X., Zeng, L., Wang, Y., Li, D., Zhan, Y., Delfouneso, D., Lew, A.M., Cui, J., Tang, W.H., Zhang, Y., Gong, S.#, Bai, F.#, Yang, M.#, and Zhang, Y.# (2019). Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways. Cell 179, 1160-1176 e1124.
3. Zhang, Y.*#, Collier, F., Naselli, G., Saffery, R., Tang, M.L., Allen, K.J., Ponsonby, A.L., Harrison, L.C.#, Vuillermin, P.#, and Group, B.I.S.I. (2016). Cord blood monocyte-derived inflammatory cytokines suppress IL-2 and induce nonclassic "T(H)2-type" immunity associated with development of food allergy. Sci Transl Med 8, 321ra328.